格🥘(ge)隆👩(long)汇🐸(hui)6月🛩(yue)27日🛣(ri)丨🛡(shu)圣🈸(sheng)诺🍪(nuo)医💪(yi)药🥫(yao)-B(02257.HK)公🍋(gong)告🏈(gao)，集🧡(ji)团🤷(tuan)已🤜(yi)完🧝(wan)成🤔(cheng)STP707的🐑(de)I期🏕(qi)临🎐(lin)床🧜(chuang)研❤(yan)究🚣(jiu)，具🚑(ju)有💙(you)较🌸(jiao)强🧔(qiang)的💝(de)安♐(an)全🎉(quan)性🦀(xing)和🔗(he)治📗(zhi)疗🌯(liao)胰🔃(yi)腺🏚(xian)癌🛡(ai)患🏃(huan)者🔮(zhe)稳🏚(wen)定🔏(ding)的🎫(de)疾🕣(ji)病👹(bing)活🚞(huo)性📄(xing)
这🤧(zhe)是🔷(shi)一😘(yi)项🌫(xiang)在🧙(zai)美📂(mei)国🤡(guo)11家✖(jia)肿🕋(zhong)瘤🎞(liu)诊🌚(zhen)所🥄(suo)进🌩(jin)行💀(xing)的🍺(de)剂🐘(ji)量📇(liang)递🚿(di)增🖼(zeng)研📓(yan)究🏒(jiu)。该🆗(gai)研✋(yan)究💩(jiu)涉👌(she)及🛴(ji)六📀(liu)组🖕(zu)，包🥢(bao)括🔧(kuo)50名🆎(ming)患🐥(huan)有📉(you)各💮(ge)种🚧(zhong)癌🧕(ai)症🎬(zheng)的🍻(de)患➕(huan)者🚟(zhe)，其🃏(qi)中🎃(zhong)11名🎀(ming)患♈(huan)有🌋(you)胰🏹(yi)腺💷(xian)癌🚔(ai)。该⏩(gai)研📸(yan)究🐂(jiu)招👡(zhao)募🐕(mu)了🚯(le)11名🦅(ming)胰🏉(yi)腺🗯(xian)癌🏪(ai)患🔳(huan)者📧(zhe)（5名🆖(ming)男🥒(nan)性Ⓜ(xing)和🕘(he)6名🈵(ming)女🈲(nv)性🕋(xing)，平🕉(ping)均🔩(jun)年🍊(nian)龄🚽(ling)64岁🐽(sui)）。在🌆(zai)参🌾(can)加🕕(jia)研🚭(yan)究👾(jiu)之🔊(zhi)前❎(qian)，患👂(huan)者❤(zhe)已🤤(yi)经🏧(jing)接🌦(jie)受⏰(shou)了🐋(le)大🎶(da)量📣(liang)治⏳(zhi)疗⛲(liao)，在⬛(zai)纳🕎(na)入🙎(ru)研🍘(yan)究🅾(jiu)之⛓(zhi)前🗑(qian)，平🍴(ping)均⛸(jun)接🚈(jie)受🆕(shou)了😼(le)三🈂(san)种😕(zhong)治👸(zhi)疗🎛(liao)方💉(fang)法🚮(fa)（包🏻(bao)括🔪(kuo)吉⌛(ji)西✨(xi)他🛵(ta)滨🐶(bin)、紫😰(zi)杉📲(shan)醇📆(chun)和🆑(he)Folfirinox）。初🙄(chu)步➿(bu)结🍌(jie)果🥊(guo)表➡(biao)明🚂(ming)，完🤐(wan)成🐠(cheng)的💹(de)平🕳(ping)均🚻(jun)治📪(zhi)疗🐛(liao)周🕔(zhou)期🏷(qi)为💲(wei)三🏫(san)个🍲(ge)周🌲(zhou)期🚋(qi)（平💼(ping)均🔽(jun)12剂🐁(ji)）。所⭕(suo)有🔶(you)11例💇(li)患⏬(huan)者📠(zhe)病🍩(bing)情🆓(qing)稳🧣(wen)定🍷(ding)的🔯(de)平🏈(ping)均👾(jun)天🎩(tian)数🗜(shu)为📔(wei)92天🔌(tian)，12mg/kg组🐊(zu)为🎸(wei)31天🈲(tian)，24mg/kg组🏯(zu)为⛔(wei)65天📤(tian)，48mg/kg组🦃(zu)为⌛(wei)112天🔪(tian)，其🕣(qi)中👧(zhong)1例🌕(li)患😊(huan)者🥚(zhe)病🔘(bing)情🎥(qing)稳🚿(wen)定⛅(ding)为🎓(wei)281天🆕(tian)。11例🚓(li)患🏇(huan)者🎇(zhe)未🤐(wei)报♊(bao)告✒(gao)治📖(zhi)疗🛢(liao)相🌧(xiang)关🎸(guan)不🤸(bu)良🥁(liang)事🎠(shi)件🤒(jian)(TRAE)，除🌎(chu)了📶(le)1例🏁(li)患🐩(huan)者👦(zhe)出🔗(chu)现👙(xian)2级🧣(ji)输💍(shu)注🐉(zhu)反🐹(fan)应🕙(ying)fei 🥌(fei)zhi 📦(zhi)liao 🌿(liao)xiang 😴(xiang)guan 📁(guan)bu 👤(bu)liang 😟(liang)shi 🎼(shi)jian 🆎(jian)ji 🌑(ji)fa 🚺(fa)yu ✊(yu)qi 🖕(qi)wan 🔀(wan)qi 🎼(qi)zhuan 📏(zhuan)yi 🀄(yi)xing 📷(xing)ji 😚(ji)bing 🦎(bing)，bao 🦉(bao)kuo 🌦(kuo)chang 🚧(chang)geng ⛸(geng)zu 🏘(zu)、fu 🧜(fu)zhang 🧢(zhang)、wei 🥁(wei)chang 🎏(chang)dao 🥤(dao)geng 🕥(geng)zu 🗺(zu)、shuan 🀄(shuan)sai 🛳(sai)、xiao 🎩(xiao)hua 🌡(hua)dao 🙀(dao)chu 🔍(chu)xue 🚥(xue)、zhong 🔒(zhong)liu 🏪(liu)teng 🛷(teng)tong 🚰(tong)、que 🔒(que)yang ⭐(yang)he 🖤(he)hu 🏖(hu)xi 🍫(xi)kun 👉(kun)nan 🔇(nan)。ji 🔕(ji)shi 🍟(shi)zai ⛎(zai)48mg/kgde 🐢(de)ji 😒(ji)liang 👡(liang)shui 📫(shui)zhun 💟(zhun)xia 🎼(xia)，suo 🏗(suo)you 🍳(you)50ming 🚅(ming)wan 🐣(wan)qi 🐹(qi)ai ➕(ai)zheng 🐦(zheng)huan 🧟(huan)zhe 🍞(zhe)reng 🕰(reng)wei 💎(wei)da 🆗(da)dao 💒(dao)STP707zui ❎(zui)da 💨(da)nai 😺(nai)shou 🌙(shou)ji 🗑(ji)liang 🦉(liang)。STP707zai 🀄(zai)yi 🈂(yi)jing 🥕(jing)jie 🤜(jie)shou 🧚(shou)guo 😨(guo)da ✒(da)liang 🕍(liang)zhi 🕵(zhi)liao 🧠(liao)de 🚋(de)ai 🐂(ai)zheng 💕(zheng)huan ♋(huan)zhe 🥫(zhe)qun 🚊(qun)ti ⛷(ti)zhong 🎮(zhong)nai 🕊(nai)shou 🈲(shou)xing 🈳(xing)fei 🏞(fei)chang 🖖(chang)hao 🔥(hao)。11ming 🌁(ming)yi 🈷(yi)xian 💤(xian)ai 🏭(ai)huan 🏋(huan)zhe 📨(zhe)zai 🎈(zai)bu 📳(bu)tong 🍼(tong)ji ✨(ji)liang ⌛(liang)xia 🔒(xia)biao ❣(biao)xian 🐏(xian)chu 📍(chu)di 🕵(di)du 🔊(du)xing 🔠(xing)he 🛤(he)xiang 🥑(xiang)dui 🏓(dui)wen 🕷(wen)ding 🛸(ding)ji 🗡(ji)bing 🙏(bing)（106、281he 🌪(he)302tian 🥨(tian)），jian 📏(jian)yu 🔴(yu)STP707zai 🕌(zai)lin 🎃(lin)chuang ⛓(chuang)qian 🕋(qian)zheng 🧛(zheng)ming ⛅(ming)de 💼(de)jiang 👪(jiang)Txi 🎙(xi)bao 🚂(bao)mu 🉐(mu)ji 🛂(ji)dao 💽(dao)zhong 🦗(zhong)liu 👨(liu)wei ⛵(wei)huan 🤣(huan)jing ⏰(jing)(TME)de 🖇(de)neng 😯(neng)li 🧤(li)，wo 🍛(wo)men 🍡(men)ren ⏩(ren)wei 👔(wei)you 🍞(you)bi 🗡(bi)yao 🚦(yao)dan 🖊(dan)du 🐴(du)shi 🦐(shi)yong 👪(yong)STP707huo 🚊(huo)yu 🍙(yu)mian 🏄(mian)yi 🕊(yi)jian 🌮(jian)zha 🤩(zha)dian 🏸(dian)yi 🉑(yi)zhi 🚧(zhi)ji ♟(ji)lian 🎬(lian)he 🎩(he)shi 👡(shi)yong 😁(yong)yi 🎿(yi)zuo 🎴(zuo)jin ✊(jin)yi 🦏(yi)bu 🧒(bu)yan 😴(yan)jiu ☔(jiu)。zhe 🔵(zhe)shi 🥕(shi)ji 🥐(ji)yu 🤣(yu)duo 🈸(duo)tai 🔙(tai)na 🕣(na)mi 🥐(mi)ke 💾(ke)li ⏩(li)de 🐷(de)siRNAai 👭(ai)zheng 🤓(zheng)zhi 🏈(zhi)liao 🍂(liao)yao 📹(yao)wu 🤸(wu)shou 🕵(shou)ci 🕛(ci)zai 🏪(zai)zhi 🍺(zhi)liao 💣(liao)wan 🐌(wan)qi 📢(qi)yi 🛺(yi)xian 😃(xian)ai 🛬(ai)huan 💳(huan)zhe 💱(zhe)fang 🧥(fang)mian 🥗(mian)xian 🤯(xian)shi 🧤(shi)chu 💅(chu)zao 🐠(zao)qi 🥈(qi)ji ⏹(ji)ji 🧖(ji)de 🐕(de)an 🏋(an)quan 🔸(quan)xing 🦏(xing)he 🌋(he)you 📞(you)xiao 💿(xiao)xing 👶(xing)jie 🤩(jie)guo 🚶(guo)。“wo Ⓜ(wo)men 🍡(men)fei 👠(fei)chang 💩(chang)gao 🏾(gao)xing ⬇(xing)di 🈯(di)kan 🌑(kan)dao ♊(dao)STP707，wo ⛹(wo)men 😖(men)ling 🐷(ling)xian 🐟(xian)de 💔(de)siRNAyao 🔓(yao)wu ♌(wu)chan 😿(chan)pin 🚮(pin)，yong 🐲(yong)yu 👲(yu)zhi 🤧(zhi)liao 🍱(liao)yi 🏊(yi)jing ♏(jing)jie 🐽(jie)shou 🔵(shou)guo 🐌(guo)da 🧝(da)liang 🏫(liang)zhi 🙂(zhi)liao 🎩(liao)de 🗞(de)yi 🏳(yi)xian 😿(xian)ai 😽(ai)（zui 🕑(zui)zhi 🕘(zhi)ming 😱(ming)de 📝(de)zhong 🧕(zhong)liu 🍩(liu)lei 🐵(lei)xing 🍱(xing)zhi 🥔(zhi)yi 🕙(yi)），zai 🐞(zai)jing 📗(jing)mai 👤(mai)gei 🧢(gei)yao 🕴(yao)hou ㊙(hou)xian 🐻(xian)shi 🎆(shi)chu 🎺(chu)zhe 😅(zhe)xie 🆖(xie)qiang 👩(qiang)da ➿(da)de 🍧(de)jie 😶(jie)guo 🌑(guo)。dui ➕(dui)yu 🤵(yu)ji 🤞(ji)yu 🌡(yu)RNAide 📪(de)ai 🔦(ai)zheng 🎰(zheng)liao 📰(liao)fa 🎻(fa)zhi 🧝(zhi)liao 🐣(liao)zhuan 🤼(zhuan)yi 📻(yi)xing 🖤(xing)zhong 🚠(zhong)liu 🧝(liu)lai 🤭(lai)shuo 🚤(shuo)，zhe 🚗(zhe)shi 🔅(shi)yi 🍣(yi)ge 🍁(ge)fei 🕧(fei)chang 🤖(chang)you 🌌(you)qian 🍲(qian)jing 😁(jing)de 🐃(de)jie 🗡(jie)guo 🕠(guo)”，Sirnaomicschuang 🏰(chuang)shi 📙(shi)ren 🤞(ren)、dong 💶(dong)shi 🐔(shi)hui ⚡(hui)zhu 🌰(zhu)xi 🎮(xi)、zhi 🏮(zhi)xing 👷(xing)dong 🕤(dong)shi 😏(shi)、zong 🎤(zong)cai 😤(cai)jian 📃(jian)shou 🚴(shou)xi 😓(xi)zhi 🕸(zhi)xing 🛎(xing)guan 🔆(guan)lu 💴(lu)yang 📸(yang)bo 🔖(bo)shi ⚽(shi)shuo 👧(shuo)。“zhe 👍(zhe)zhong 🔂(zhong)jing 🖨(jing)mai 🤰(mai)zhu 🖥(zhu)she ❄(she)de 📌(de)STP707zhi 🆖(zhi)ji 🌖(ji)ju 🤰(ju)you ⚾(you)qiang 📤(qiang)da 🌴(da)de 🍦(de)an 🍓(an)quan 📘(quan)xing ✝(xing)、chi 🤐(chi)jiu 🏯(jiu)wen 📺(wen)ding 🍻(ding)de 🌇(de)ji 🚌(ji)bing 👊(bing)liao 💸(liao)xiao 📡(xiao)he 🧙(he)ji 🏊(ji)liang 🌩(liang)yi 😱(yi)lai 👳(lai)xing 🥐(xing)kang 📳(kang)zhong 🚍(zhong)liu 🧦(liu)huo 🤾(huo)xing 🔸(xing)，wu 🍀(wu)lun 👠(lun)shi 👚(shi)zuo 🛑(zuo)wei 📣(wei)dan 💜(dan)yi ✔(yi)yao 🀄(yao)wu 🥀(wu)hai 👲(hai)shi 🕦(shi)yu 🔃(yu)mian 🥚(mian)yi 📷(yi)jian 🍄(jian)zha 🤯(zha)dian 🥣(dian)yi 🐑(yi)zhi 🙈(zhi)ji 💻(ji)yao 〽(yao)wu 🐏(wu)lian 📭(lian)he 🔦(he)shi 🧤(shi)yong 📩(yong)，dou ❔(dou)shi ♈(shi)yi 🎥(yi)zhong 👿(zhong)qian ⛩(qian)zai 🐉(zai)de 🔯(de)xin 💇(xin)xing ⛅(xing)ai 🎈(ai)zheng ♊(zheng)zhi 🛍(zhi)liao 😆(liao)fang 🏫(fang)fa ⤴(fa)”。